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Journal Article 6

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cartilage 3

Cartilage tissue engineering 1

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Head and neck reconstruction 1

Intra-articular 1

Orthopedic surgery 1

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Preclinical immunocompetent animal 1

Rheumatoid arthritis 1

Serum amyloid A 1 1

Tissue engineering 1

bioinformatics analysis 1

biomechanics 1

bone 1

characterization 1

condylar cartilage 1

dentin matrix protein 1 1

extracellular matrix 1

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Tissue engineering of cartilage, tendon and bone

Hengyun SUN, Wei LIU, Guangdong ZHOU, Wenjie ZHANG, Lei CUI, Yilin CAO

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 61-69 doi: 10.1007/s11684-011-0122-1

Abstract: In our laboratory, we focus on construction of cartilage, tendon and bone.In cartilage engineering, articular cartilage was reconstructed and defects were repaired in animal modelsMore sophisticated tissues, such as cartilage in the ear and trachea, were reconstructed both in

Keywords： Tissue engineering     cartilage     bone     tendon     recent advances    

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iTRAQ-based quantitative proteomic analysis on differentially expressed proteins of rat mandibular condylar cartilage

Liting Jiang,Yinyin Xie,Li Wei,Qi Zhou,Ning Li,Xinquan Jiang,Yiming Gao

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 97-109 doi: 10.1007/s11684-016-0496-1

Abstract: reducing dietary loading directly influences the development and metabolic activity of mandibular condylar cartilagetartrate-resistant acid phosphatase staining indicated the altered histological structure of condylar cartilage

Keywords： condylar cartilage     mechanical loading     proteomic analysis     iTRAQ     bioinformatics analysis    

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Recent Progress in Cartilage Tissue Engineering—Our Experience and Future Directions

Yu Liu, Guangdong Zhou, Yilin Cao

Engineering 2017, Volume 3, Issue 1,   Pages 28-35 doi: 10.1016/J.ENG.2017.01.010

Abstract: approaches for cartilage regeneration.There are two major applications for tissue-engineered cartilage.One is in orthopedic surgery, in which the engineered cartilage is usually used to repair cartilage defectsor loss in an articular joint or meniscus in order to restore the joint function.by the engineered cartilage for the other application.

Keywords： Cartilage tissue engineering     Preclinical immunocompetent animal     investigation     Clinical translation     Orthopedic    

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Characterization of the surface and interfacial properties of the lamina splendens

Joe T. REXWINKLE, Heather K. HUNT, Ferris M. PFEIFFER

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 2,   Pages 234-252 doi: 10.1007/s11465-017-0409-2

Abstract: The development of treatment programs for joint disease and trauma requires accurate assessment of articularcartilage degradation.The articular cartilage is the interfacial tissue between articulating surfaces, such as bones, and actsDamage to the lamina splendens, which is the articular cartilage’s topmost layer, is an early indicatorcartilage, thereby leading to rational treatment programs for joint disease and injury.

Keywords： cartilage     lamina splendens     characterization     biomechanics     orthopaedic     review    

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Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis

Hui Xue, Dike Tao, Yuteng Weng, Qiqi Fan, Shuang Zhou, Ruilin Zhang, Han Zhang, Rui Yue, Xiaogang Wang, Zuolin Wang, Yao Sun

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 575-589 doi: 10.1007/s11684-019-0693-9

Abstract: Crucial to fracture healing is cartilage formation, which provides a bone-regeneration environment.Cartilage consists of both chondrocytes and extracellular matrix (ECM).The ECM of cartilage includes collagens and various types of proteoglycans (PGs), which play importantThe PG form of dentin matrix protein 1 (DMP1-PG) is involved in maintaining the health of articular cartilage

Keywords： fracture     extracellular matrix     dentin matrix protein 1     proteoglycan     cartilage    

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Roles of Serum Amyloid A 1 Protein Isoforms in Rheumatoid Arthritis Article

Elaine Lai-Han Leung, Huan-Ling Lai, Run-Ze Li, Hu-Dan Pan, Ze-Bo Jiang, Ying Li, Fu-Gang Duan, Jia-Hui Xu, Yi-Zhong Zhang, A-Xi Shi, Chun-Li Wei, Fang-Yuan Zhang, Xiao-Jun Yao, Liang Liu

Engineering 2022, Volume 10, Issue 3,   Pages 174-182 doi: 10.1016/j.eng.2020.08.018

Abstract:

Secondary amyloid A amyloidosis, a lethal complication, is induced when acute or chronic infection coexists with over-secretion of the serum amyloid A 1 (SAA1) protein and deposition in key internal organs. Previously, using the whole-exome sequencing method, we identified a novel deleterious mutation SAA1.2 in rheumatoid arthritis (RA) patients. However, the role of SAA1 in RA pathogenesis and its complications remains unknown. The purpose of this study was to determine the pathogenetic roles of SAA1 protein isoforms in RA progression. We modified an experimental adenovirus infection protocol to introduce SAA1.2 gene alleles into the knee joints of mice and used SAA1.3 and SAA1.5 as controls. Micro-computed tomography analysis was applied to determine changes in bone morphology and density. Immunohistochemical (IHC) analysis, flow cytometry, enzyme-linked immunosorbent assay (ELISA), and real-time polymerase chain reaction (RT-PCR) were used to investigate disease progression and cytokine alterations in the course of adenoviral SAA-induced knee joint inflammation and bone destruction. We found that the arthritis-inducing effect of SAA1.2 transcription in the knee joints and mutant SAA1 protein secretion in blood resulted in the stimulation of immune responses, leading to CD8+ T cell and pro-inflammatory cytokine elevation, such as interleukin (IL)-6, IL-22, matrix metalloproteinase (MMP)-3, MMP-9, with subsequent synovial inflammation and bone destruction. These findings indicate that SAA1 protein isoforms, particularly SAA1.2, play a significant role in the induction and progression of RA and may have potential value in the early diagnosis and severity prediction of RA.

Keywords： Serum amyloid A 1     Rheumatoid arthritis     Pathogenetic     Intra-articular    

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Title Author Date Type Operation

Tissue engineering of cartilage, tendon and bone

Hengyun SUN, Wei LIU, Guangdong ZHOU, Wenjie ZHANG, Lei CUI, Yilin CAO

Journal Article

iTRAQ-based quantitative proteomic analysis on differentially expressed proteins of rat mandibular condylar cartilage

Liting Jiang,Yinyin Xie,Li Wei,Qi Zhou,Ning Li,Xinquan Jiang,Yiming Gao

Journal Article

Recent Progress in Cartilage Tissue Engineering—Our Experience and Future Directions

Yu Liu, Guangdong Zhou, Yilin Cao

Journal Article

Characterization of the surface and interfacial properties of the lamina splendens

Joe T. REXWINKLE, Heather K. HUNT, Ferris M. PFEIFFER

Journal Article

Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis

Hui Xue, Dike Tao, Yuteng Weng, Qiqi Fan, Shuang Zhou, Ruilin Zhang, Han Zhang, Rui Yue, Xiaogang Wang, Zuolin Wang, Yao Sun

Journal Article

Roles of Serum Amyloid A 1 Protein Isoforms in Rheumatoid Arthritis

Elaine Lai-Han Leung, Huan-Ling Lai, Run-Ze Li, Hu-Dan Pan, Ze-Bo Jiang, Ying Li, Fu-Gang Duan, Jia-Hui Xu, Yi-Zhong Zhang, A-Xi Shi, Chun-Li Wei, Fang-Yuan Zhang, Xiao-Jun Yao, Liang Liu

Journal Article